Features Vancogenx® HV is the high viscosity bone cement loaded with Gentamicin and Vancomycin. Its high viscosity makes it suitable for manual applications. Antibiotics are released locally and is useful as a coadjuvant in the treatment of an infection. Available in the 40g pack. Periprosthetic infections constitute one of the most critical post-operative complications in arthroplasty. The surface of the implant is a perfect environment for the adhesion and growth of bacteria. It is particularly difficult to treat infections due to MRSA (Methicillin-Resistant Staphylococcus aureus), MRSE (Methicillin-Resistant Staphylococcus epidermidis), and other resistant pathogens, which continue to represent a serious and widespread problem. Vancogenx® HV is the ideal bone cement for the fixation of antibiotic-loaded spacers during two-stage procedures in case of periprosthetic joint infection (PJI) and prosthetic components fixation during revision surgery following a septic process. Benefits of Vancogenx® HV Broad scpectrum of activity due to antibiotic synergy Effective as a coadjuvant in the treatment of an infection High and effective release of Vancomycin and Gentamicin Bacterial anti-adhesion thanks to the presence of antibiotics Approved for fixation of definitive revision prostheses Approved for cementation of antibiotic-loaded spacers VANCOGENX® HV: Synergy When combined, Gentamicin and Vancomycin have a synergistic action against bacteria.1-2-3 Their range of action covers approximately 90% of the pathogenic agents generally isolated in surgical infections.3-4 The Gentamicin and Vancomycin combination is the most commonly used and published combination in cases of concomitant treatment of orthopaedic infections. 5-6-7 VANCOGENX® HV: Effectiveness Vancogenx® HV bone cement has been shown to be able to prevent bacterial adhesion3 (in vitro tests) and as a coadjuvant in treatment of the infection (in vivo animal tests).8 In vitro studies have shown that Vancogenx® HV exerts an anti-adhesion action by inhibiting bacterial proliferation. In vivo animal studies have proven Vancogenx® HV’s therapeutic efficacy in experimental osteomyelitis models. The results of the study indicate that local therapy with Vancogenx® HV is able to eradicate infection and provides better results than systemic therapy with teicoplanin.8 Following surgical debridement, the local therapy achieved with Vancogenx® HV eradicates infection and provides better results than systemic therapy. Bibliography - 1. Watanakunakorn C, et al.Antimicrob Agents Chemother. 1973; 2. Watanakunakorn C, et al.Antimicrob Agents Chemother. 1982; 3. E. Bertazzoni Minelli, et al. Anaerobe. 2011; 4. Trampuz A, et al. Swiss Med Wkly. 2005; 5. Penner MJ, et al. J Arthroplasty. 1996; 6. Masri BA, et al. J Arthroplasty. 1998; 7. Bertazzoni Minelli E, et al. J Chemother. 2002; 8. Giavaresi G. et al. J Orthop Res. 2008
| Product Code : | Vancogenx® HV |
| Category : | Bone Cement With Gentamicin And Vancomycin |
Features Vancogenx® HV is the high viscosity bone cement loaded with Gentamicin and Vancomycin. Its high viscosity makes it suitable for manual applications. Antibiotics are released locally and is useful as a coadjuvant in the treatment of an infection. Available in the 40g pack. Periprosthetic infections constitute one of the most critical post-operative complications in arthroplasty. The surface of the implant is a perfect environment for the adhesion and growth of bacteria. It is particularly difficult to treat infections due to MRSA (Methicillin-Resistant Staphylococcus aureus), MRSE (Methicillin-Resistant Staphylococcus epidermidis), and other resistant pathogens, which continue to represent a serious and widespread problem. Vancogenx® HV is the ideal bone cement for the fixation of antibiotic-loaded spacers during two-stage procedures in case of periprosthetic joint infection (PJI) and prosthetic components fixation during revision surgery following a septic process. Benefits of Vancogenx® HV Broad scpectrum of activity due to antibiotic synergy Effective as a coadjuvant in the treatment of an infection High and effective release of Vancomycin and Gentamicin Bacterial anti-adhesion thanks to the presence of antibiotics Approved for fixation of definitive revision prostheses Approved for cementation of antibiotic-loaded spacers VANCOGENX® HV: Synergy When combined, Gentamicin and Vancomycin have a synergistic action against bacteria.1-2-3 Their range of action covers approximately 90% of the pathogenic agents generally isolated in surgical infections.3-4 The Gentamicin and Vancomycin combination is the most commonly used and published combination in cases of concomitant treatment of orthopaedic infections. 5-6-7 VANCOGENX® HV: Effectiveness Vancogenx® HV bone cement has been shown to be able to prevent bacterial adhesion3 (in vitro tests) and as a coadjuvant in treatment of the infection (in vivo animal tests).8 In vitro studies have shown that Vancogenx® HV exerts an anti-adhesion action by inhibiting bacterial proliferation. In vivo animal studies have proven Vancogenx® HV’s therapeutic efficacy in experimental osteomyelitis models. The results of the study indicate that local therapy with Vancogenx® HV is able to eradicate infection and provides better results than systemic therapy with teicoplanin.8 Following surgical debridement, the local therapy achieved with Vancogenx® HV eradicates infection and provides better results than systemic therapy. Bibliography - 1. Watanakunakorn C, et al.Antimicrob Agents Chemother. 1973; 2. Watanakunakorn C, et al.Antimicrob Agents Chemother. 1982; 3. E. Bertazzoni Minelli, et al. Anaerobe. 2011; 4. Trampuz A, et al. Swiss Med Wkly. 2005; 5. Penner MJ, et al. J Arthroplasty. 1996; 6. Masri BA, et al. J Arthroplasty. 1998; 7. Bertazzoni Minelli E, et al. J Chemother. 2002; 8. Giavaresi G. et al. J Orthop Res. 2008
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